Diabetes Drugs and Weight Loss
Diabetes drugs have changed weight loss efforts in a number of ways. Some diabetes drugs have been found to promote weight loss, while others may cause weight gain.
In recent years, several new drugs have emerged in the weight loss industry that have shown promising results in helping people achieve significant weight loss. Among these drugs are Wegovy / Oxempic (Semaglutide) and Mounjaro. These medications have been found to be effective in helping people lose weight and maintain weight loss over the long term, and they are changing the way we approach weight loss.
GLP-1 Agonists – Wegovy & Oxempic (Semaglutide)
One class of diabetes drugs that has been associated with weight loss is the GLP-1 agonists. Wegovy & Ozempic, brand names for Semaglutide are GLP-1 receptor agonists that was initially approved to treat type 2 diabetes.These drugs work by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1), which is released by the gut in response to food. GLP-1 agonists slow down stomach emptying, which can lead to reduced appetite and lower food intake. They may also increase feelings of fullness after a meal. As a result, many people taking GLP-1 agonists like Wegovy /Ozempic reduce their overall calorie intake, and experience weight loss as a side effect. In clinical trials, Semaglutide has been shown to help people lose an average of 15-20% of their body weight over the course of a year.
Mounjaro, also known as Tirzepatide, is a medication that was initially approved in Europe for weight loss. Mounjaro acts on GLP-1 and GIP (glucose dependent insulinotropic polypetide) receptors where Wegovy / Ozempic only acts on the GLP-1 receptor. By blocking these receptors, Mounjaro can help to reduce cravings and promote weight loss.
Another class of diabetes drugs that may contribute to weight loss are SGLT-2 inhibitors. These include ertugliflozin (Steglatro), dulaglutide (Trulicity), bexagliflozin (Brenzavvy), canagliflozin (Invokana), ertugliflozin (Steglatro), dapagliflozin (Farxiga) and empagliflozin (Jardiance). These drugs work by blocking the reabsorption of glucose in the kidneys, which leads to increased glucose excretion in urine. This can help lower blood sugar levels and also leads to loss of calories in the form of glucose, which may contribute to weight loss.
On the other hand, some diabetes drugs, such as insulin and certain oral medications like sulfonylureas, Glimepiride (Amaryl), Glipizide and Glyburide have been associated with weight gain. Insulin can cause weight gain by increasing the storage of fat and by stimulating the appetite. Sulfonylureas may also stimulate the appetite, leading to increased calorie intake.
Of course, it’s important to note that these medications are not a magic solution for weight loss or gain. They should be used in conjunction with a healthy diet and regular exercise in order to achieve optimal results. Additionally, they may not be appropriate for everyone, and it’s important to speak with a healthcare provider before starting any new medication
These medications have transformed the weight loss industry by providing people with new and effective tools for achieving and maintaining weight loss. In the past, weight loss medications were often associated with significant side effects, limited effectiveness, or concerns about long-term safety. However, these new medications have been shown to be effective, safe, and well-tolerated in clinical trials.
It is important to note that diabetes drugs should be used under the guidance of a healthcare professional and in conjunction with a healthy diet and exercise plan to achieve optimal weight loss and blood sugar control.